【摘要】 目的:评价瑞芬太尼复合麻醉用于小儿室间隔缺损修补术安全性和有效性。方法:选择室间隔缺损需行心内直视手术患儿20例,随机分为2组,Ⅰ组芬太尼总剂量30μg/kg,Ⅱ组瑞芬太尼0.05～1.00μg/(kg·min)持续泵入。分别于不同时间记录血液动力学参数,并采集动脉血标本测量应激激素浓度,观察术后机械通气时间和拔管时间。结果:与Ⅰ组相比,Ⅱ组在术中各时点血液动力学参数和应激激素浓度差异均无统计学意义,但术后通气时间和拔管时间均显著缩短。结论:瑞芬太尼复合麻醉维持术中血液动力学稳定,有效抑制应激激素释放,实施术后早期拔管,用于小儿室间隔缺损修补术复合麻醉安全有效。更多还原

【Abstract】 Objective: To evaluate the efficiency and safety of remifentanil combined anesthesia in children undergoing ventricular septal defect repair. Methods: Twenty children scheduled for surgical repair of ventricular septal defects were randomized into two groups: GroupⅠwith fentanyl at a total dose of 30 μg·kg-1, group Ⅱ with continuously infusion of remifentanil at 0.05-1.00 μg/(kg·min).The hemodynamics parameters and blood level of stress hormone at different time points during the operation were monitored. The duration of mechanical ventilation and extubation time were also recorded. Results: There was no significant difference between the two groups on hemodynamics parameters and blood level of stress hormone. The duration of mechanical ventilation and extubation time in group Ⅱ were notably shorter than those of group Ⅰ. Conclusion: Remifentanil could be safely and effectively used in children undergoing ventricular septal defect repair, with stable hemodynamics, effective inhibition of stress hormones release and early extubation.更多还原