【摘要】 目的:研究高同型半胱氨酸血症与脑梗死患者高凝状态的关系。方法:测定114例脑梗死患者和110例健康对照组的同型半胱氨酸、凝血酶原片段1+2、纤维蛋白肽A、可溶性纤维蛋白单体复合物、抗凝血酶-Ⅲ、蛋白C、组织纤溶酶原激活物活性、纤溶酶原、纤溶酶原激活抑制物-1活性、叶酸、维生素B12。结果:与对照组比较,脑梗死患者叶酸、维生素B12水平显著低于对照组(P<0.01),而同型半胱氨酸水平显著高于对照组(P<0.01),患者组凝血、抗凝血、纤溶系统各项指标均发生显著性改变(P<0.01),其水平均与同型半胱氨酸水平显著相关。结论:由于叶酸、维生素B12缺乏所致的高同型半胱氨酸血症与脑梗死患者凝血、抗凝血、纤溶系统的异常显著相关,对促进血栓形成具有重要影响。更多还原

【Abstract】 Objective: To study the relationship between the level of homocysteine and hypercoagulable state in the cerebral infarction patients.Methods: Homocysteine,prothrombin fragment,the fibrin peptide A,the soluble fibrin monomer complex,the antithrombin-Ⅲ,protein C,D-dimer,tissue plasminogen activator,plasminogen,plasminogen activator inhibitor,folic acid and vitamin B12 were determined in the 114 cerebral infarction patients and the 110 controls.Results: Compared the normal group with the patients group of cerebral thrombosis,the parameters of the patients group had obviously change(P<0.01)which have significantly relationship with the level of homocysteine.Conclusion: There is strong relationship between the high level homocysteine(which were caused by lack of the folic acid and vitamin B12) and the change of the coagulation,anticoagulation,fibrinolytic system,and it plays an important role in the thrombosis.更多还原