【摘要】 目的:探讨乙肝病毒基因产物HBsAg,HBcAg,HBxAg在乙型肝炎相关性肝癌中的表达及其在肝细胞癌变中的作用。方法:采用组织芯片技术和免疫组织化学染色方法对152例乙型肝炎相关肝细胞肝癌组织、78例乙型肝炎后肝硬化组织中HBsAg,HBcAg,HBxAg的表达进行检测。结果:和乙型肝炎后肝硬化相比,在乙型肝炎相关性肝癌组织中HBsAg表达显著降低(P=0.000);HBcAg表达显著增高(P=0.000);HBxAg显著增高(P=0.005)。结论:乙肝病毒抗原成分HBcAg,HBxAg参与乙型肝炎相关性肝癌的发生。更多还原

【Abstract】 Objective:To study the expression of the products of HBV genome,HBsAg,HBcAg and HBxAg in hepatitis-related carcinoma.Methods:A total of 152 cases of carcinomas and 78 cases of post-hepatitis liver cirrhosis were stained by immunohistochemical methods combined with tissue chip to detect the expression of the HBV antigen HBsAg,HBcAg,HBxAg.Results:The expression of HBcAg,HBxAg was significantly higher in carcinoma than that in cirrhosis(P=0.000 and P=0.005 respectively).The expression of HBsAg was significantly lower in carcinoma than that in cirrhosis(P=0.000).Conclusion:HBcAg and HBxAg take part in the carcinogensis of hepatitis-related hepatocellular carcinoma.更多还原