【摘要】 目的探讨在体外循环(cardiopulmonary bypass,CPB)下心脏手术围术期检测血清补体C3、C4水平变化的临床意义。方法选择20例进行CPB手术和20例非CPB手术围术期中几个时期的血液(包括术前、术后即刻、术后24 h、术后48 h和术后72 h),测定其血清补体C3、C4的水平。结果CPB组患者血清补体C3水平在CPB停流转后显著低于术前水平(0.67±0.29 g/Lvs1.36±0.61 g/L,P<0.01),术后2 d恢复并显著高于术前水平(1.71±0.51 g/Lvs1.36±0.61 g/L,P<0.01);血清补体C4水平在CPB停流转后显著低于术前水平(0.14±0.07vs0.27±0.16 g/L,P<0.01),术后3 d恢复并显著高于术前水平(0.35±0.18 g/Lvs0.27±0.16 g/L,P<0.01);对照组各项指标较术前均无显著变化(P>0.05)。结论CPB围术期观察血清补体C3、C4水平对心脏外科临床有着指导作用。更多还原

【Abstract】 Objective To explore the clinical value of the determination of the kinetic levels of serum complement 3（C₃） and complement 4（C₄） during perioperation of cardiopulmonary bypass（CPB） surgery.Methods C₃ and C₄ were determined in 20 patients with heart diseases and 20 patients with other thoracic diseases before and after the surgery（24 h,48 h and 72 h respectively）.Results C₃ decreased markedly after CPB cardiac surgery,its levels being lower significantly than those before the surgery in CPB group （0.67±0.29 g/L vs 1.36±0.61 g/L,P<0.01）,and the levels of C₃ returned to certain range 48 h after operation which were even much higher than those before the surgery（1.71±0.51 g/L vs 1.36±0.61 g/L,P<0.01）.C₄ also decreased markedly after the surgery,its levels being lower significantly than those before the surgery in CPB group（0.14±0.07 vs 0.27±0.16 g/L,P<0.01）,and the levels of C₄ returned to certain range 72 h after operation which was even much higher than those before the surgery（0.35±0.18 g/L vs（0.27）±0.16 g/L,P<0.01）.There was no difference significantly in these parameters in control group（P>0.05）.Conclusion C₃ and C₄ are of definite significance in monitoring clinical state in patients during perioperation of CPB surgery.更多还原