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SUR1基因多态性与脂代谢相关性研究

An Investigation on the Relationship between Sulfonylurea Receptor 1 Gene Polymorphism and the Metabolism of Blood Lipid

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【Author】 WANG Chun~1,WU Guo-ting~1,YU Yong-chun~2,TENG Xiao-hong~2,WANG Ji-ying~1,WANG Yan-bo~3(1.Dept.of Endocrinology,Tenth People’s Hospital Affiliated to Tongji University,Shanghai 200072,China;2.Dept.of Central Laboratory,Tenth People’s Hospital Affiliated to Tongji University,Shanghai 200072,China;3.Dept.of Medical Technology,Institute of Technology,Tongji University,Shanghai 200072,China)

【机构】同济大学附属第十人民医院内分泌科；同济大学附属第十人民医院中心实验室；同济大学高等技术学院医学分院上海200072；上海200072；上海200070；

【摘要】目的通过对上海地区2型糖尿病一级亲SUR1基因多态性的研究,探讨SUR1基因对脂代谢的影响。方法上海地区2型糖尿病一级亲共114人。选定SUR1基因16号外显子多态性位点,运用PCR-RFLP方法对每位入选者均进行基因型分析并经测序证实。测定空腹总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、甘油三酯等临床指标。结果高密度脂蛋白胆固醇:c/t基因型高于t/t基因型,差异存在显著性。结论SUR1基因16号外显子-3c→t多态性多态性与胆固醇代谢存在相关性。更多还原

【Abstract】 Objective To investigate the polymorphism of sulfonylurea receptor 1 gene and the metabolism of blood lipid.Methods One hundred and fourteen type 2 diabetes mellitus family members,the polymorphism of SUR1 exon 16 –3c→t were analyzed.The genotype of everyone involved was determined by PCR-RFLP and identified by sequencing.Cholesterol,HDL-C,LDL-C and triglyceride were measured at the same time.Results The levels of HDL:c/t genotype was higher than t/t genotype.Conclusion The polymorphism in sulfonylurea receptor 1 gene exon 16-3c→t was associated with the metabolism of cholesterol.更多还原

【关键词】 SUR1；基因；多态性；聚合酶链反应；限制性片段长度多态性；胆固醇；
【Key words】 SUR1； gene； polymorphism； PCR； RFLP； cholesterol；

【文献出处】同济大学学报(医学版) ,Journal of Tongji University(Medical Science) , 编辑部邮箱 ,2006年03期

【分类号】R589
【下载频次】86

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