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Synthesis of Protected Tetrapeptide, N-o-Ns-N(Me)-Val-N(Me)-Val-N(Me)-Val-N(Me)-Phe-O~tBu

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【Author】 CHEN Hongliang, FENG Yaqing, MENG Shuxian, LIU Xingang(School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China)

【机构】 School of Chemical Engineering and Technology Tianjin University； School of Chemical Engineering and Technology Tianjin University； Tianjin 300072 China Tianjin 300072 China Tianjin 300072 China Tianjin 300072 China；

【Abstract】 The protected tetrapeptide, N-o-Ns-N（Me）-Val-N（Me）-Val-N（Me）-Val- N（Me）-Phe-O^tBu, was prepared from L-valine and L-phenylalanine. Tert-butyl acetate and HClO₄ were used to protect carbonyl group, o-nitrobenzenesulfonyl chloride and triethyl amine were used to protect amino group, and N-alkylation was finished with iodomethane. Then the protected amino acid was turned into acid chloride which was taken as coupling reagent. After 14 steps, such as protection, alkylation, deprotection and coupling, the protected tetrapeptide was obtained with a yield of 26.9⁰/₀. The structures of intermediates and target compound were identified with NMR spectra and high resolution mass spectra.更多还原

【关键词】 synthesis； tetrapeptide； L-valine； L-phenylalanine；
【Key words】 synthesis； tetrapeptide； L-valine； L-phenylalanine；

【文献出处】 Transactions of Tianjin University ,天津大学学报(英文版) , 编辑部邮箱 ,2006年05期

【分类号】O629.72
【下载频次】18

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