【摘要】 目的探讨悦肝胶囊对四氯化碳(CC l4)损伤原代培养大鼠肝细胞的保护作用。方法以CC l4诱导大鼠肝细胞损伤模型,观察悦肝胶囊对肝细胞的琥珀酸脱氢酶(SDH)、酸性磷酸酶(ACPase)、葡萄糖-6-磷酸酶(G-6-Pase)活性和糖原含量以及肝细胞形态结构的影响。结果悦肝胶囊能显著提高SDH、G-6-Pase活性及糖原含量,抑制ACPase活性,并可显著改善受损肝细胞的形态结构变化。结论悦肝胶囊对CC l4损伤原代培养大鼠肝细胞具有保护作用。更多还原

【Abstract】 ObjectiveTo investigate the effects of Yuegan Capsule on CCl₄-intoxicated primary cultured rat hepatocytes.MethodsHepatocytes injury models were induced by CCl₄ in rats in vitro,and treated with Yuegan capsule.Structure of rat hepatocytes and effect of SDH、ACPase、G-6-Pase activeties and amount of hepatic glycogen were observed.ResultsThe Yuegan Capsule increased the activity of SDH,G-6-Pase and the amount of hepatic glycogen,and restrain the activity of ACPase,and could improve the changes of rat hepatocytes structure.ConclusionYuegan capsule has protective effects on CCl₄-induced injury of primary cultured rat hepatocytes.更多还原