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纳米铜复合材料宫内节育器对家兔子宫内膜超微结构的影响

Influence of Nano-Cu/LDPE-IUD on Ultrastructure of Rabbit Endometrium

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【作者】 狄海红朱长虹谢长生夏先平甄波刘子龙

【Author】 Hai-hong DI1,Chang-hong ZHU1,Chang-sheng XIE2,Xian-ping XIA2,Bo ZHEN1,Zi-long LIU1(1.Family Planning Research Institute of Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430030)(2.Material Institute,Huazhong University of Science and Technology,Wuhan,430074)

【机构】 华中科技大学同济医学院计划生育研究所华中科技大学材料学院华中科技大学同济医学院计划生育研究所 武汉430030武汉430074

【摘要】 目的:评价纳米铜/低密度聚乙烯复合材料宫内节育器(IUD)的安全性。方法:实验家兔分为对照组、裸铜组、低剂量纳米铜组(0.5-1.0μg/d)和高剂量纳米铜组(1.1-2.0μg/d)。于置器后56d取子宫内膜做扫描电镜和透射电镜检查。结果:裸铜组家兔子宫内膜上皮细胞微绒毛排列不规则,胞浆内出现大空泡,微丝结构增多,粗面内质网扩张,细胞间连接装置变宽。纳米铜组家兔子宫内膜上皮细胞微绒毛脱落,细胞形态基本正常,细胞核结构正常,胞浆内粗面内质网轻度扩张,细胞间连接装置正常。结论:形态学改变相比较说明纳米铜IUD对家兔子宫内膜超微结构影响较轻,对子宫内膜的刺激作用较小,从而可能会减少置IUD初期子宫异常出血、疼痛等不良反应的发生。

【Abstract】 Objective:To evaluate the influence of Nano-Cu/LDPE-IUD on ultrastructure of rabbit endometrium.Methods:Thirty-two rabbits were divided randomly into control group,Cu-IUD group,low dose(10 μg/d)and high dose(20 μg/d)Nano-Cu/LDPE IUD groups.The endometrial tissues of the rabbits were studied by scanning and transmission electron microscopy 56 d after insertion of Cu-IUD and Nano-Cu/LDPE-IUD.Results:Irregular pattern of microvilli of epithelial cells,big vacuole and swollen mitochondria in cytoplasm,increased microfilaments and broadened cell-cell junction were observed in Cu-IUD group.The morphological changes of Nano-Cu/LDPE-IUD groups were characterized by shed microvilli of epithelium cells,normal nuclear structure and shape of epithelium cells,slight swollen mitochondria in cytoplasm and normal cell-cell junction.Conclusion:The morphological information of the groups was compared,stimulation caused by Nano-Cu/LDPE-IUD was gentler than that induced by Cu-IUD,Nano-Cu/LDPE-IUD could lessen abnormal bleeding and pain caused by Cu-IUD.

【基金】 国家科技攻关项目(No.2004BA709B14-01)
  • 【文献出处】 生殖与避孕 ,Reproduction & Contraception , 编辑部邮箱 ,2006年10期
  • 【分类号】R169.41
  • 【被引频次】17
  • 【下载频次】140
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