【摘要】 目的检测胃癌患者血浆基质金属蛋白酶-9在胃癌中表达及其临床意义。方法采用抗MMP-9MOAb建立了MMP-9血浆酶免疫测定法。检测血浆基质金属蛋白酶-9在胃癌中的阳性表达率及其与胃癌的病理类型、淋巴结转移、侵袭程度的关系。结果胃癌组36例,阳性率50%(18/36),对照组20例,阳性率5%(1/20),两组差异有显著性(P<0.01)。血浆基质金属蛋白酶-9与胃癌的侵袭程度、淋巴结转移密切相关(P<0.01),与胃癌的病理类型无关(P>0.05)。结论胃癌患者血浆基质金属蛋白酶-9较对照组明显增高,且与胃癌侵袭程度,淋巴结转移密切相关。血浆基质金属蛋白酶-9的检测,是对胃癌前病变监测及判断胃癌的生物学特征重要指标,对胃癌的预后评估具有重要的临床意义。更多还原

【Abstract】 Objective To investigate the expression of MMP-9 in gastric carcinoma and identify the relationship between expression of MMP-9 and tumor invasion, metastasis. Methods In 56 cases of gastric carcinoma and healthy persons, serum enzyme-linked immunoassay analysis was used to observe the expression of MMP-9. The pathological type, the tumor invasive depth and lymph node metastasis were analyzed at the same time. Results The positive rate of MMP-9 expression was 50% (18/36) in gastric carcinoma, but 5% (1/20) in the control group (P< 0.01). There were significant differences between the positive expression of MMP-9 and depth of invasion, lymphatic metastasis (P< 0.01), except of the pathological type (P> 0.05). Conclusion [WT5”BZ]The serum MMP-9 in gastric carcinoma was significantly higher than that in the healthy person and closely correlated with gastric carcinoma invasive depth and lymph node metastasis. Detection of MMP-9 could be helpful in monitoring the gastric pre-cancerous lesions, judging the biological character of gastric cacinoma and predicting patient’s prognosis.更多还原