【摘要】 目的:探讨全子宫切除术后雌、孕激素水平的变化与子宫内膜组织中相应受体的量化关系。方法:选择我院因子宫肌瘤行全子宫切除术的未绝经病人70例(观察组),根据术后标本中测得子宫内膜组织雌激素受体含量分为3组,A组,雌激素受体平均含量>80%;B组,50%～80%;C组,<50%。所有病人分别于术前经净7d内及术后6个月同一日早晨空腹抽血测卵泡刺激素(FSH)、黄体生成激素(LH)、雌二醇(E2)、孕酮(P),另同时选择体检人群中健康妇女30例作为对照组。结果:观察组患者术前所测FSH、LH、P与对照组相比差异无显著性,E2明显升高,差异有显著性。术后半年A、B、C3组分别与术前比较FSH、LH(C组除外)均明显升高,E2明显降低,差异有显著性(P<0.05),P无明显变化;术后组间比较,A组FSH、LH明显高于C组,E2明显低于C组,差异有显著性;B、C组术后FSH均上升但两组间差异无显著性,LH均上升,但B组上升较C组明显,差异有显著性,E2均下降,但两组间差异无显著性。结论:全子宫切除术后半年卵巢功能明显衰退,且子宫内膜组织中雌激素受体含量高的A组较受体含量低的B、C两组卵巢功能改变更明显,证实了子宫内膜受体在生殖内分泌系统中起重要的调节作用。更多还原

【Abstract】 Objective To evaluate the quantitative relationship between the ch anges of plasma estrogen and progestogen and the related receptors of endometriu m after the uterectomy.Methods Seventy patients whose uterus were excised were chosen in our hospital because of hysteromyoma,and devided into 3 groups accordi ng to the contents of estrogen receptor(ER)of endometrium after the operation,E R >80%as group A,ER 50%～80%as Group B and ER< 50%as Group C.The blood sam ples of all the patients were collected within 7 days after the menstruation bef ore operation and the same day of 6 months after operation in the empty stomach to exam the contents of FSH,LH,E2 and P in the body.Another 30 healthy women we re chosen as control group.Results Campared with control group,the levels of FS H,LH and P of 70 patients before operation showed no difference,but the level of E2 rose significantly in the group A,B and C.After half a year of opetration,t he levels of FSH and LH(except for group C)significantly increased,while the le vel of E2 significantly decreased(P< 0.05),and the level of P has no obvious cha nge as compared with prior to the operation.After the operation,the levels of F SH and LH in group A and group B were higher than that in group C,and the level of E2 was lower than that in group C.Conclusions Ovary function has obviously d eclined after half a year of the uterectomy,the higher content of ER in the tiss ue of endometrium,the more obvious the declination of ovary function.It is show n that the receptors of endometrium play an important role in the endocrine syst em of reproduction.更多还原