【摘要】 目的:探讨各类肝炎患者血清前白蛋白(PA)、胆碱酯酶(ChE)和透明质酸(HA)、层粘蛋白(LN)、Ⅳ型胶原(IVC)、Ⅲ型前胶原氨端肽(PⅢNP)等血清肝纤维化指标与肝组织病理损害的相关性。方法:观察292例经肝活检证实的各类肝炎患者血清PA、ChE水平和血清肝纤维化指标的变化,并将其与肝组织活检的炎症分级和纤维化分期进行相关性分析。结果:肝脏病理组织炎症分为G1～G4级,纤维化分为S0～S4期。炎症轻重两组间PA、ChE和血清肝纤维化指标差异均有显著性(P<0.01)。随着纤维化程度的增加,PA、ChE逐渐下降,而血清肝纤维化指标逐渐升高,且S4与S0～S3比较差异有显著性(P<0.01)。PA、ChE和血清肝纤维化指标与炎症分级及纤维化分期之间的相关性均非常显著(P<0.01)。结论:PA、ChE和血清肝纤维化指标能较好地反映肝脏的炎症活动水平且能较敏感地反映肝脏的纤维化程度,联合检测有可能成为较好的无创性诊断方法。更多还原

【Abstract】 Objective To investigate the relationship between serum prealbumin(PA),cholinesterase(ChE),fibrosis markers and pathological injury of hepatic tissue in patients with all kinds of hepatitis.Methods Detection of serum PA,ChE and serum fibrosis markers together with liver biopsy was performed in 292 patients with hepatitis.The relationship between those serum components and the grade of inflammation,fibrosis staging in hepatic tissue was analyzed.Results There was a significant difference of PA,ChE and fibrosis markers between the lower grade and higher grade of inflammation(P< 0.01).Serum PA and ChE were gradually decreased but fibrosis markers elevated with the progression of hepatic fibrosis,making a marked difference between fibrosis S0～S3 and S4(P< 0.01).The relationship between serum PA,ChE,fibrosis markers and the grade of inflammation,fibrosis staging was highly significant(P< 0.01).Conclusions Serum PA,ChE and fibrosis markers can signal the level of liver inflammation activity and the extent of hepatic fibrosis.Combined detection of PA,ChE and fibrosis markers may be a noninvasive diagnostic method for the severity of hepatitis.更多还原