【摘要】 目的探讨下咽癌单纯手术、术后放疗和术后放疗+化疗的临床疗效。方法回顾性分析1979年2月~2002年10月收治的下咽癌120例。单纯手术组(简称S组)30例,术后放疗组(简称S+R组)60例,术后放疗和化疗组(简称S+R+C组)30例。随访中位时间42.7个月。结果根据Kaplan-Meier方法统计S组、S+R组、S+R+C组3、5年生存率分别为34.9%、30.4%,47.5%、42.9%,56.1%、47.3%。S组3、5年生存率和S+R组及S+R+C组3、5年生存率存在显著性差异(χ2=8.87,P=0.003,χ2=4.74,P=0.029,χ2=11.47,P=0.009,χ2=13.22,P=0.001),S+R组和S+R+C组3年生存率存在显著性差异(χ2=3.42,P=0.047),S+R组和S+R+C组5年生存率差异无显著性(χ2=2.60,P=0.279)。结论术后放疗明显提高了下咽癌3、5年生存率,应该成为下咽癌首选的治疗方法。合并化疗的综合治疗未能明显提高下咽癌5年生存率。更多还原

【Abstract】 Objective To evaluate the survival rates of patients received surgery alone, or with adjuvant radiotherapy and/or chemotherapy among those with hypopharyngeal carcinoma. Methods Survival rate of 120 patients with hypopharyngeal carcinoma from February 1979 through October 2002 were retrospectively reviewed, 30 patients received surgery alone (S group), 60 patients received additional adjuvant radiotherapy after surgery (S+R group), and 30 patients received adjuvant radiotherapy and chemotherapy after surgery (S+R+C group). The median follow up period was 42.7months. Results Kaplan Meier method was used in the evaluation of survival rate, and Logrank test for statistical analysis between them. The 3-and 5-year survival rates were 34.9%, 30.4%; 47.5%, 42.9 %; 56.1%, and 47.3% for the S group, S+R group and S+R+C group respectively. There were significant differences in the 3-and 5-year survival rates between S and S+R group ( χ2=8.87, P=0.003; χ2=4.74, P=0.029); and also between the S and S+R+C group ( χ2= 11.47 , P=0.009; χ2=13.22, P=0.001). There were significant differences in 3 year survival rate between S+R group and S+R+C group (χ2=3.42, P=0.047), but no significant differences existed in the 5 year survival rate between S+R and S+R+C group (χ2=2.60, P=0.279). Conclusions Postoperative radiotherapy obviously improves the 3-and 5-year survival rates of patients with hypopharyngeal carcinoma, and postoperative radiotherapy should be performed as a routine. Combined with chemotherapy do not increase the 5-year survival rate in patients with hypopharyngeal carcinoma.更多还原