【摘要】 目的:探讨2型糖尿病血清脂蛋白(a)[Lp(a)]水平及其变化的临床意义。方法:采用免疫透射比浊法测定了20例正常人2、0例冠心病患者和70例2型糖尿病(DM)患者的血清Lp(a)水平,综合考虑其血清尿素氮(BUN)、肌酐(CRE)、尿微量白蛋白(mAlb)水平,将70例2型糖尿病患者分为2组:2型糖尿病无肾病组40例(BUN<7.30 mmol/L,CRE<105μmol/L,mAtb<11.7 mg/L),糖尿病肾病(DN)组30例(BUN>7.30 mmol/L,CRE>105μmol/L)。结果:正常人和2型糖尿病无DN组间血清Lp(a)水平差异无显著性(P>0.05);糖尿病肾病组Lp(a)水平显著升高(P<0.05),这一点与冠心病患者相似。2型糖尿病患者中,血清Lp(a)水平与mAlb呈简单正相关关系(r=0.03,P<0.05),多元线性回归分析显示,mAlb未能进入多元回归方程。结论:2型糖尿病患者无DN时,血清Lp(a)水平与非糖尿病患者相比差异无显著性;2型糖尿病合并DN患者出现血清Lp(a)水平显著增高,且与尿微量白蛋白呈正相关关系,提示Lp(a)水平升高可能继发于DN的肾脏损害,随肾脏损害进展而逐步升高。更多还原

【Abstract】 Objective:To investigate the serum Lipoprotein(a)[Lp(a)]level in type 2 diabetes mellitus and sense of alternative.Methods:Serum Lp(a) concentration was measured in 20 normal person,20 coronary heart disease patients and 2 group of type 2 diabetes mellitus patients including 40 without diabetes nephritis(DN)(BUN<7.30 mmol/L,CRE<105 μmol/L,mAlb<11.7 mg/L);30 patients with DN(BUN>7.30mmol/L,CRE>105 μmol/L).Serum Lp(a) concentration in every patient groups were compared with that in normal person.Result:Lp(a) levels were similar between type 2 diabetes mellitus patients without DN and natural person.But in patients with DN,Lp(a) level significantly increased as compared with above-mentioned two groups,this is like the coronary heart disease patients.There was a positive correlation between Lp(a) concentration and mAlb(r=0.03,P<0.05).Conclusion:Lp(a) levels might be normal in type 2 diabetes mellitus patients without DN,but it could increase in type 2 diabetes mellitus patients with DN and might be related with renal impairment.更多还原