【摘要】 目的:探讨尖锐湿疣(CA)组织中环氧化酶-2(COX-2)和血管内皮生长因子(VEGF)的表达及意义。方法:用免疫组化法分别检测COX-2和VEGF蛋白在30例CA组织和10例正常上皮组织中的表达。结果:COX-2和VEGF在正常上皮组织均有极少量弱的表达,在CA组织均呈强阳性表达;COX-2和VEGF蛋白表达呈正相关。结论:COX-2和VEGF表达呈正相关,COX-2和VEGF在CA发生、发展中起一定作用,表明COX-2可能与肿瘤血管形成有关。更多还原

【Abstract】 Objective To detect COX-2 and VEGF protein in keratinocytes of condyloma acuminatum(CA),and explore their roles in pathogenesis.Methods The expression of COX-2 and VEGF protein in 30 cases of CA and 10 normal controls were detected respectively by immunohistochemistry staining.Results There were no expression of COX-2 and VEGF in normal skin tissue,while there were overexpression of COX-2 and VEGF in CA tissue;there was a statistically positive correlation between COX-2 and VEGF protein overexpression in CA.Conclusion There is a statistically positive correlation between COX-2 and VEGF protein overexpression in CA;the study indicated that overexpression of COX-2 protein in CA is brelated with tumour blood vessel formation.更多还原