【摘要】 目的对唇形科香茶菜属植物狭基线纹香茶菜(Isodon lophanthoides(Buch.Ham.ex D.Don)Haravar.gerandianus(Benth.)Hara)即中药溪黄草的化学成分进行研究。方法体积分数为95%乙醇提取物的水混悬液经环己烷、乙酸乙酯、正丁醇分步萃取,再对乙酸乙酯层运用硅胶、D101大孔树脂S、ephadex LH 20、ODS等柱层析手段并配合HPLC进行分离、纯化;通过化学方法及波谱分析鉴定其结构。结果分离得到并鉴定了6个化合物:既6去羟基迷迭香酸甲酯(methyl 6 dehy-droxyl rosmarinate,1)、迷迭香酸甲酯(methyl rosmarinate,2)、咖啡酸(caffeic acid,3)、6,7二羟基香豆素(6,7 dihydroxycoumarin,4)、槲皮素(quercetin,5)、蓟黄素(cirsimaritin,6)。结论化合物1为新天然产物,化合物4为首次从该属中分离得到,化合物3、6为首次从该植物中分离得到。更多还原

【Abstract】 Objective To isolate and identify the constituents of Isodon lophanthoides(Buch.-Ham.ex D.Don)Hara var.gerandianus(Benth.)Hara.Methods Various chromatographic techniques,spectral methods as well as physical and chemical means were used to isolate and identify constituents from I.Lophanthoides(Buch.-Ham.ex D.Don)Hara var.gerandianus(Benth.)Hara.Results Six compounds were obtained and determined as methyl-6dehydroxyl rosmarinate(1),methyl rosmarinate(2),caffeic acid(3),6,7-dihydroxycoumarin(4),quercetin(5)and cirsimaritin(6).Conclusions Among them,compound 1 is a new natural product;compound 4 is isolated from the genus Isodon for the first time,compounds 2 and 6 are isolated from this plant for the first time.更多还原