【摘要】 目的通过大鼠急性心肌梗死心室重构模型观察人参皂苷Rb1对心室重构的影响。方法结扎雄性SD大鼠左冠状动脉前降支制备急性心肌梗死(AM I)模型,随机分为AM I对照组(n=7)和人参皂苷Rb1治疗组(n=8,简称Rb1治疗组),另设假手术组(n=8)。Rb1治疗组经腹腔注射人参皂苷Rb1(4mg.kg-1.d-1),假手术组及AM I对照组给予同量的0.9%氯化钠溶液,4周后检测大鼠血流动力学及形态学参数,免疫组化法检测左室非梗死区Ⅰ型胶原表达。结果与假手术组比较,AM I对照组左室重量指数、左室截面直径、Ⅰ型胶原含量及左室舒张末压(LVEDP)均明显增高,差异有非常显著性意义(P<0.01),而左室收缩压(LVSP)及左室内压最大上升和下降速率均明显降低,差异有非常显著性意义(P<0.01);与AM I对照组比较,Rb1治疗组左室重量指数、左室截面直径、Ⅰ型胶原含量及LVEDP、左室梗死面积均明显降低,差异有显著性意义(P<0.01或<0.05),而LVSP及左室最大上升和下降速度均明显增高,差异有显著性意义(P<0.05)。三组间心率差异无显著性意义。结论人参皂苷Rb1能有效抑制急性心肌梗死大鼠的心室重构,保护心功能。更多还原

【Abstract】 Objective To investigate effects of Ginsenoside Rb1 on left ventricular（LV） remodeling in rats with acute myocardial infraction（AMI）.Methods Fifteen male Sprague Dawley rats surviving AMI,which was achieved by ligating coronary artery,were randomized to AMI control group （n=7） or Ginsenoside Rb1 treatment group（n=8）.Sham-operated rats（n=8） were selected randomly.After surgery,treatment of Ginsenoside Rb1(4mg·kg^-1·d^-1,for treatment group) or saline（for AMI control and sham-operated groups） was started by intraperitoneal injection.After 4 weeks of treatment,hemodynamic studies and morphological analysis were performed and the collagen Ⅰ of LV non-infarct zone were detected with immunohistochemical staining.Results Compared with Sham-operated rats,ratio of left ventricular weight to body weight（LVW/BW）,left ventricular diameter（LVD）,type Ⅰ collagen content and the LV end diastolic pressure（LVEDP） in AMI control group were significantly increased（P<0.01）,while the LV systolic pressure（LVSP）,the maximum rising and dropping rates of LV pressure in AMI control group were significantly reduced（P<0.01）.In contract,compared with AMI control group,LVW/BW,LVD,type Ⅰ collagen content,LVEDP and size of MI in Ginsenoside Rb1 treatment group were significantly decreased（P<0.01 or 0.05）.While LVSP and the maximum rising and dropping rates of LV pressure in AMI were significantly increased（P<0.05）.There were no significant difference on the heart rate（HR） among the three groups.Conclusion Ginsenoside Rb1 can prevent and treat LV remodeling after AMI in rats efficiently.更多还原