【摘要】 目的研究高张盐溶液对失血性休克的治疗与细胞的保护作用。方法用动脉放血至平均动脉压(MAP)为5·33kPa维持30min制作失血性休克的动物模型,分别用不同浓度的NaCl溶液治疗休克,观察MAP、血浆电解质(Na+、Cl-、K+)、血浆N-乙酰-β-葡萄糖酐酸酶(NAG)活性、丙二醛(MDA)浓度和动物存活时间。结果7·5%NaCl组中MAP明显高于其他浓度的NaCl组,血浆K+却明显低于其他浓度的NaCl组,并且血浆NAG、MDA也明显低于其他组,家兔的存活时间最长。结论7·5%NaCl溶液治疗早期失血性休克,可以减轻细胞损伤程度,提高动物的存活时间,明显优于其他浓度的高渗盐液。更多还原

【Abstract】 Objective To research the effects of hypertonic saline on the treatment and cell function in hemorrhagic shock.Methods It was reproduced that an animal model of hemorrhaged(MAP=5.33kPa) for 30 minutes in rabbits.It was treated by saline solution,grouped as 5 groups in 0.9%、2.5%、5.0%、7.5%、10.0%NaCl.It was analyzed in MAP and Na~+、Cl~-、K~+、NAG、MDA in plasma and survival times in rabbits.Results The MAP of 7.5% NaCl groups was significantly greater than others,but the level of K~+、NAG、MDA was significantly lower than others,the survival times in 7.5% NaCl groups were the longest among the 5 groups.Conclusion These studies suggest that cell injury may be decreased in resuscitation with 7.5% NaCl in hemorrhagic shock.更多还原