【摘要】 目的总结先天梅毒新生儿的临床特点,探讨诊断和治疗措施。方法回顾33例先天梅毒新生儿的病史资料、临床表现、诊断依据及治疗方案。将抗梅毒治疗所需天数作为疗效反应指标,并据此分组,<21 d属敏感组,≥21 d者为不敏感。比较两组性别、胎龄、出生体质量、入院年龄、重要脏器合并症及母亲妊娠期抗梅毒治疗是否存在差异。结果除3例剔除病例,余30例患儿均好转或治愈出院,无死亡病例。先天梅毒新生儿同时存在2个或2个以上重要脏器合并症者18例(54.55%)。两组胎龄、重要脏器合并症及母亲妊娠期是否接受抗梅毒治疗比较均有显著差异,P均<0.05。结论经正规抗梅毒治疗,先天梅毒可治愈,但其预后取决于病原体已造成的损害程度。更多还原

【Abstract】 Objective To Study the clinical characteristic of congenital syphilis,and discuss the issues of diagnosis and therapy.Methods Thirty-three primary congenital syphilis infants′ case history,clinical manifestation,diagnosis evidence,and treatment program were reviewed.The various days of anti-syphilis therapy were regarded as the treatment outcome level, by which divided infants into sensitive and non-sensitive subgroups.The two subgroups′ gender,gestational age,birth weight,admission age,clinical complication and maternal anti-syphilis therapy during gestational period were compared.Results Rejected 3 cases,totally 30 infants were enrolled and no one dead.There were 18 infants had two and above important complication. The gestational age,clinical complication and maternal antisyphilis therapy during gestational period had a significant deviation between two subgroups(all P<0.05).Conclusions Congenital syphilis neonates can be cured whose prognosis is associated with present organic damage.It is most important to emphasis prenatal diagnosis and earlier reorganization,as well as disease prevention.更多还原