【摘要】 目的测定不同年龄阶段小儿外周血B淋巴细胞CD21表达水平,以探讨其临床意义。方法将住院非感染患儿分成新生儿组、婴幼儿组和儿童组,收集外周血1.8 mL,进行流式细胞仪检测,测定不同年龄组CD21的B淋巴细胞和CD21表达位点数目。结果1.新生儿外周血表达CD21的B淋巴细胞数目明显低于婴幼儿组和儿童组,且随年龄增长,其数值亦呈渐升高趋势。2.B淋巴细胞表达CD21平均荧光强度有渐增强特点。结论随小儿年龄增长,B淋巴细胞CD21表达渐上调,符合不同年龄段小儿免疫系统发育特点,也反映特定年龄段由于B淋巴细胞CD21高表达,而造成对EB病毒的易感性。更多还原

【Abstract】 Objective To investigate the clinical significance of the expression of CD₂₁ on peripheral blood B lymphocytes in different age periods.Methods All the cases was divided into newborn group,infant group and children group.The expression of CD₂₁ on B lymphocytes were analyzed by the flow cytometry.Results 1.The number of CD₂₁ on B lymphocytes of newborn group were obviously lo-（wer） than those in other two groups;and with growth of a child,the numer tended to grow up.2.Mean fluorescence intension（MFI）,the expression of CD₂₁ on B lymphocyte,also had the characteristic of increase with the age.Conclusions With the growing up of a child,the expression of CD₂₁ on B lymphocyte has the tendency of up-regulation;which conforms to the feature of immune system development in childhood.Because of the higher expression of CD₂₁ on B lymphocyte in certain age,it has the sensitivity to Epstein-Barr virus infection for children.更多还原