【摘要】 目的观察过敏性紫癜(HSP)患儿血浆肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)的改变及应用低分子肝素后的变化。方法HSP患儿43例,其中肝素治疗组28例,基础治疗组15例。低分子肝素钙注射液前后7 d,采用酶联免疫法测定血浆TNFα-、IL-8水平。结果HSP组血浆TNF-α、IL-8明显高于健康对照组,均有显著性差异(P均<0.01)。肝素治疗组血浆TNF-α、IL-8治疗后明显低于治疗前,差异均有显著性(P均<0.01)。结论细胞因子异常可能参与HSP及紫癜性肾炎的发病过程,低分子肝素治疗可降低其血浆TNF-α、IL-8水平。更多还原

【Abstract】 Objective To observe the plasma level of tumor necrosis factor-α(TNF-α)and interleukin-8(IL-8) in children with Henoch-Schonlein purpura(HSP)and the changes of above parameters after therapy with low molecular weight heparin.Methods Forty-three HSP patients,heparin group(n=28) and conventional therapy group(n=15) were studied.The plasma levels of TNF-α and IL-8 were observed with ELISA assay in 7 days before and after therapy.Results The plasma levels of TNF-α and IL-8 were ob-viously higher in HSP patients than those in control group(all P<0.01).TNF-α and IL-8 in HSP patients were found remarkably decreasing after heparin therapy(all P<0.01).Conclusions Abnormal cytokine may involve in the development of HSP and HSP nephritis.The plasma levels of TNF-α and IL-8 can be decreased after therapy with low molecular weight heparin.更多还原