【摘要】 目的探讨血小板生成素(TPO)和巨核细胞计数对特发性血小板减少性紫癜(ITP)患儿预后的意义。方法采用夹心酶联免疫吸附法测定122例ITP患儿血清TPO水平,根据巨核细胞数分为A组(巨核细胞数≤35/6 cm2)与B组(巨核细胞数>35/6 cm2),两组进行TPO水平比较,并观察各组疗效。结果A和B组TPO水平分别为(368.33±39.47)ng/L,(141.48±11.28)ng/L。A组明显高于B组,有显著性差异(t=7.44 P<0.01)。A组治疗有效率为23.8%,明显低于B组84.2%,其差异有显著性(χ2=6.54 P<0.05)。A组有效5例TPO为(109.60±15.59)ng/L,无效16例TPO为(449.18±29.59)ng/L,其差异有显著意义(t=-6.23 P<0.01)。结论ITP患儿血清TPO水平存在较大差异,TPO水平明显增高且无巨核细胞数增高者疗效差,可能提示预后不良。更多还原

【Abstract】 Objective To explore the prognosis of idiopathic thrombocytopenic purpura(ITP) in serum levels of thrombopoietin(TPO) and number of megakaryocyte.Methods Serum levels of TPO were measured with sandwich-enzyme linked immunosorbent assay kit.According to the number of megakaryocyte,the patients were divided into group A(the number of megakaryocyte was less than or equal to 35/6 cm~2) and group B(the number of megakaryocyte is higher than 35/6 cm~2) and reviewed their curative effects.Results The mean serum level of TPO in group A was(368.33±39.47) ng/L and that in group B was(141.48±11.28) ng/L.The serum levels of TPO in group A were visibly higher than those in group B.There was statistical difference between group A and group B(t=7.44 P<0.01).The therapeutic effective power in group A was 23.8% and remarkably decreased than 84.2% in group B(χ~2=6.54 P<0.05).The mean serum TPO levels in 5 responders in group A [(109.60±15.59) ng/L] was significantly lower than that in 16 nonresponder in group A[(449.18±29.59) ng/L] in treatment(t=-6.23 P<0.01).Conclusions There is markedly difference in serum level of TPO in children with ITP.The high level of TPO and lower number of megakaryocyte prognosticated infaust prognosis in ITP.更多还原