【摘要】 目的探讨HIE患儿血浆内皮素(ET)、降钙素基因相关肽(CGRP)及心钠素(ANP)的变化及其临床意义。方法应用放射免疫分析法和离子交换法测定46例HIE和26例正常新生儿的血浆ET、CGRP、ANP和血清钠、钙水平。结果HIE组急性期血浆ET、CGRP和ANP水平明显高于对照组及恢复期组(P均<0.001));病情越重,ET、CGRP和ANP水平越高,恢复期血浆ET、CGRP和ANP水平渐下降,中重度组下降的幅度更为缓慢。HIE中重度组血钠水平明显低于对照组(P<0.05);不同程度HIE组血钙水平均明显低于对照组,差异显著(P<0.01)。HIE组治疗前后血浆ET与CGRP、ANP水平呈直线正相关,急性期血浆ET与血钙、血浆ANP与血钠之间无明显相关性(P均>0.05)。结论血浆ET、CGRP和ANP共同参与HIE发病机制及病理过程,其动态变化有助于病情判断、疗效评价及预后评估。更多还原

【Abstract】 Objective To investigate the interaction and clinical significance of blood endothelin(ET),calei tonm gene-related peptide(CGRP),atrial natriuretic peptide(ANP) in neonatal hypoxic-ischemic encephalopathy(HIE).Methods Blood ET,CGRP,ANP and serum Na,Ca of 46 cases of HIE and 26 normal newborns were measured by radioimmunoassay and ion exchange technique.Results In HIE group,blood ET,CGRP,ANP were obviously higher in acute period than those in convalescence and control group(all P<(0.001)).And the levels of ET,CGRP,ANP were related to the state of the illness.In the convalescence,the level of blood ET,CGRP,ANP descended gradually,especially the moderate and severe group descended slowly.The levels of serum Na were obviously lower in the moderate and severe group compared with that in control group((P<0.05));The level of serum Ca in different group was lower compared with that in control group.Blood ET,CGRP,ANP were positively connected in HIE group before and after therapy.In acute period,there was no obvious relation between blood ET and serum Ca blood ANP and serum Na(all P>0.05).Conclusions Blood ET,CGRP,ANP are concerned with pathogenesis and pathologic process,their variety help to judge the state of the illness,evaluate curative effect and prognosis.更多还原