【摘要】 目的探讨糖皮质激素受体(GCR)水平对肾病综合征(NS)疗效的影响,观察绞股蓝、刺五加对GCR水平的调节作用。方法设正常对照组、治疗Ⅰ组(单用激素组)、治疗Ⅱ组(绞股蓝、刺五加与激素合用组),采用放射配体结合法分别测定各组GCR,同时观察各组同期24 h尿蛋白定量。结果与正常对照组相比,治疗Ⅰ组和Ⅱ组GCR水平均降低,治疗4周后治疗Ⅱ组不仅GCR水平恢复较治疗Ⅰ组快,且尿蛋白消退亦快。结论绞股蓝、刺五加对NS患儿GCR有调节作用,有消除尿蛋白、治疗NS的作用。更多还原

【Abstract】 Objective To study the effect of glucocorticoid receptor(GCR) on the treatment of patients with nephrotic syndrome(NS) and to observe the accommodation effect of herbal gynostemmae,acanthopanax senticosus harns on GCR levels.Methods The patients were divided into 3 groups: the healthy control group,treatment group Ⅰ(GC only) and treatment group Ⅱ(combination with herbal gynostemmae,acanthopanax senticosus harns and GC),radioligand binding assay was used to measure the GCR levels of each group.At the same time,the urine protein ratio within 24 hours was observed in each group.Results Compared with healthy control group,the GCR levels of treatment group Ⅰ and Ⅱ were both reduced,but after 4 weeks of treatment in the treatment group Ⅱ,not only GCR level recovered but also the urine protein were decreased faster than treatment group Ⅰ.Conclusions Herbal gynostemmae,acanthopanax senticosus harns can accommodate the GCR levels of children with NS.They can also eliminate urine protein and cure NS ideally.更多还原