【摘要】 新生儿缺氧缺血性脑病(HIE)是指围生期窒息导致新生儿缺氧缺血性脑损伤,国内外的诊断标准存在较大差别,虽然目前国内已将脐动脉血气分析纳入诊断指标当中,但在指标的表述上仍较国际标准相对宽松,易造成误诊,国外标准较严格,可导致漏诊。目前国内外标准中在诊断意义上亦存在一定局限性,所以临床应结合病史、Apgar评分、脐动脉血气分析及临床表现,借助多种辅助检查方法进行综合评估。更多还原

【Abstract】 Objective To investigate the changes of plasma somatostatin(SS) and its correlation with cellular immune function in neonates with hypoxic-ischemic encephalopathy(HIE).Methods Fifty cases of HIE were collected to detect the SS and T lymphocyte subsets,IL-2,sIL-2R as well as IL-6 levels by radioimmunoassay,APAAP and doule antibody sandwith ELISA methods.Results The SS and sIL-2R levels in patients with HIE were significantly higher(P<0.01),While the proportion of CD4~+/CD8~+,the percentages of CD3~+ and CD4~+ T subtype and IL-2 as well as IL-6 levels were significantly lower(P<0.01) than those in control group.The SS levels in patients with HIE had significantly negative corrections with the proportion of CD4~+/CD8~+,the percentages of CD3~+ and CD4~+ T subtype,IL-2 and IL-6 levels,and a significant positive corrlation with levels of sIL-2R(P<0.01).Conclusions High level of SS is related to HIE,and there is a strong negative correlation between SS and cellular immune function in patients with HIE.更多还原