【摘要】 目的探讨老年短暂性脑缺血发作(TIA)与C反应蛋白(CRP)和血浆D-二聚体(D-dimer,D-D)的关系。方法将中国医科大学附属第二医院2003-06~2005-06收治的92例老年TIA患者按病程划分为3组:TIA持续60min内缓解为A组(35例);TIA超过60min,并反复发作,但无持久的神经缺损症状,无脑梗死发生者为B组(31例);以TIA起病,以后发展成为脑梗死为C组(26例)。所有病例在起病24h内检测血清CRP和D-D的质量浓度,观察72h内头CT或MRI,将结果与正常对照组28名进行组间比较。结果TIA患者血清CRP和D-D的质量浓度高于对照组(P<0·01),B、C组均高于A组(P<0·01),且C组高于B组(P<0·05),TIA各组CRP和D-D质量浓度均呈显著正相关。结论(1)CRP是D-D升高的主要相关因素。(2)CRP和D-D的升高可能是老年TIA患者的危险因素。(3)CRP和D-D的升高可以对老年TIA患者的诊断、治疗和估计预后提供较可靠的实验室指标。更多还原

【Abstract】 Objective To investigate the relationship between transient ischemic attack(TIA)of the aged and serum CRP and plasma D-dimer.Methods A total 92 TIA aged patients,who were admitted to the Second Hospital of China Medical University of China Medical University from June 2003 to June 2005,were divided into three groups of A,B and C.All cases were measured within 24 hours the CRP and D-dimer.Head CT or MRI were carried out within 72 hours,and compared with control group,and compared between different groups of TIA.Results The levels of serum CRP and plasma D-dimer with TIA of the aged were higher than control group(P<0.01).The levels of serum CRP and plasma D-dimer of B and C groups were higher than A group(P<0.01),and the level was obviously different between B and C group(P<0.05).The correlative analysis of all groups with TIA demonstrated that plasma D-dimer had obvious positive relationship with CRP.Conclusion (1)CRP is major factor related to the rise of D-dimer.(2)The increase of the levels of CRP and D-dimer may be a dangerous factor for the aged patients with TIA.(3)The increase of the levels of CRP and D-dimer can provide a reliable index of laboratory observation of diagnosis,treatment and estimating prognosis.更多还原