【摘要】 目的探讨人群β2-肾上腺素能受体(β2-AR)16、27位点基因多态性与慢性阻塞性肺疾病(COPD)的关系。方法收集2003-03~2004-04在贵州省人民医院呼吸内科住院的COPD患者63例及健康对照组31例共94份样品,采用等位基因特异性聚合酶链反应(PCR)技术,检测β2-AR基因编码区第16、27氨基酸变异位点,进行分析。结果COPD患者和健康人群β2-AR基因27位点Gln/Gln纯合子基因型分布频率分别为42·86%、19·35%,差异有显著性(P<0·05)。结论β2-AR基因27位点Gln/Gln纯合子基因型与COPD的易感性有关。更多还原

【Abstract】 Objective To investigate the relationship between the genetic polymorphisms of β₂-adrenergic receptor and the chronic obstructive pulmonary disease.Methods Allele specific-PCR technique was used to determine 16、27 locos of β₂-AR genetic polymorphism in 64 unrelated patients with chronic obstructive pulmonary disease and 31 healthy controls in the Department of Respiratory Medicine,People’s Hospital of Gui zhou province from Mar.2003 to Apr.2004.Results In COPD group and the healthy group the frequency of Gln/Gln genotype of β₂-AR 27 locus was 42.86%and 19.35%respectively.It showed significantly difference between them（P<0.05）.Conclusion The Gln/Gln genotype of β₂-AR 27 locus is associated with the susceptibility of COPD.更多还原