【摘要】 目的观察奥美拉唑对反流性食管炎的疗效。方法80例经内镜证实的反流性食管炎患者口服奥美拉唑20mg,2次/d,分别于治疗2、4、6周时观察反酸、烧心、反食等症状疗效,并于治疗6周后胃镜复查对炎症的疗效。结果奥美拉唑治疗2周,即可见症状明显改善,症状记分较治疗前明显下降(P<0.01),治疗2、4、6周,症状治疗显效率分别为52.5%,81.3%及87.5%(治疗4周及6周与治疗2周相比,P<0.01)。治疗6周症状改善总有效率为95.0%。6周后Ⅰ级食管炎治愈率为92.3%,高于Ⅱ级80.0%,Ⅲ级与Ⅳ级治愈率为62.5%(P<0.05)。结论奥美拉唑是治疗反流性食管炎的有效药物。更多还原

【Abstract】 Objective To evaluate the effect of omeprazole in the treatment of reflux esophagitis.Methods 80 patients with reflux esophagitis diagnosed by endoscopy were given each 20 mg of omeprazole po.,qd.2,4 and 6 weeks after the beginning of the medication,the effects of the drug on the symptoms such as sour regurgitation,heart burn and reflux of food were kept under observation.Gastroscopy was repeated 6 weeks after the beginning of the treatment for appraising the cure rate.Results 2 weeks of omeprazole treatment resulted in a dramatic abatement of symptoms,with a significant decrease in the symptoms scores(P<0.01).The rates of significant effectualness of symptomatic treatment were 52.5%,81.3%and 87.5% after 2,4 and 6 weeks of medication,respectively.(Rates of the 4 th and 6 th weeks versus rate of the 2 nd week,P<0.01).The total effective rate of symptom abatement was 95.0% after 6 weeks of treatment.At the same time,the cure rate of Grade I esophagitis(92.3%)was higher than that(80.0%)of Grade Ⅱ esophagitis.The cure rate of Grade Ⅲ and Grade Ⅳ esophagitis was 62.5%.The differences,however,were insignificant.Conclusion Omeprazole was found to be an effective medicine in the treatment of reflux esophagitis.更多还原