【摘要】 目的探讨血清降钙素原(PCT)在儿科细菌感染性疾病诊断中的应用价值。方法采用半定量固相免疫测定法测定106例儿科感染性疾病患者血清PCT水平,并与C-反应蛋白(CRP)及外周血白细胞(WBC)计数比较,分析各指标在细菌及病毒感染中的差异。结果以血清PCT≥0.5ng/ml为阳性阈值,细菌感染组PCT阳性率为81.0%,病毒感染组为18.6%,两组比较有显著性差异(P<0.01)。PCT对细菌感染诊断敏感性达80.9%,特异性为81.4%,阳性预测值86.4%、阴性预测值74.5%,敏感性明显优于CRP或WBC计数(P<0.01)。结论血清PCT可作为细菌感染的敏感、有效诊断指标,对鉴别儿科细菌感染与病毒感染具有重要参考价值。更多还原

【Abstract】 Objective To investigate the clinical significance of serum procalcitonin(PCT)in the diagnosis of bacterial infectious diseases in pediatrics patients.Methods 106 children with various infectious diseases were enrolled in this study. Serum PCT was measured by semi-quantitative solid-phase immunoassay. C-reactive protein (CRP) and white blood cells (WBC) count were also determined. The difference in bacterial and viral infectious groups was compared between each index.Results Take serum PCT≥0.5ng/ml as a positive threshold, PCT was positive in 81.0% of children in bacterial infectious group, which was significantly higher than that in virus infectious groups (18.6%,P<0.01). The sensitivity, specificity, positive predictive value and negative predictive value of serum PCT test in diagnosing bacterial infectious diseases were 81.0 %, 81.4%, 86.4% and 74.5% respectively. The predictive value of PCT is better than CRP and WBC count(P<0.01).Conclusion Serum PCT could be used as a sensitive and effective diagnostic marker for bacterial infection in children.更多还原