【摘要】 目的:观察引导性骨再生(guidedboneregeneration,GBR)技术修复腭裂骨缺损的效果。方法:16只成年犬分为2组:实验组8只,对照组8只。实验组将rhBMP-2/Co/PLGA复合生物膜植入骨缺损区,对照组植入Co/PLGA复合生物膜。分别于术后第4、8、12、24周,对其上颌骨进行三维CT扫描观察,同时进行新骨组织学检查。结果:从影像学、组织学检查的结果看,实验组的新骨形成优于对照组。结论:植入rhBMP-2/Co/PLGA复合生物膜可用于修复腭裂骨缺损。更多还原

【Abstract】 Objective:To study whether the guided bone regeneration (GBR) technique can be used to achieve good bone formation in the defects of palate. Methods:Bone defect in the shape of triangle with the height of 4 cm and base line of 1.5 cm was created in the middle of palate in each of 16 adult dogs. The dogs were equally divided into experimental group(A) and control group(B). rhBMP-2/Co/ PLGA membrane was implanted in the defects in group A and the Co/ PLGA membrane in group B. The maxillary bone were observed by CT scan at 4, 8, 12 and 24 weeks after operation. The defect repair was observed by histological examination. Results:CT and histological examinations showed that new bone formation in group A was better than that in group B. 24 weeks after operation the defects in group A were completely repaired by new bone, those in group B partly repaired. Conclusion:The rhBMP-2/Co/PLGA composite membrane can be used to repair the defects in palate.更多还原