【摘要】 目的探讨激素性股骨头缺血坏死模型的血脂变化规律及其与MSCT灌注成像的相关性。方法1~1.5年龄新西兰大耳白兔20只,包括实验组16只,每周2次臀肌注射甲强龙8 mg/kg,在给药2、4、6、8周周末各处死4只;对照组4只,在2、4、6、8周周末各处死1只。所有动物于处死前行血脂和MSCT灌注检查,获得甘油三脂(TR IG)、胆固醇(CHOL)、股骨头血流量(Perfusion)、峰值增强值(PEI)、峰值增强时间(TTP)、平均通过时间(MTT)等指标。血脂指标、MSCT灌注参数进行相关性分析。动物处死后取双侧股骨头制作病理切片,光镜观察。结果在给予激素后2周TR IG、CHOL明显增加,并随着给药时间的延长呈逐渐增加的趋势;在给予激素后2周股骨头内血流量开始下降,随着时间的延长下降更明显,股骨头内PEI和MTT仅在给药后4周有所下降。TR IG、CHOL的增加与股骨头血流量的下降有统计学的显著相关性。结论激素性股骨头缺血坏死动物模型血脂的增加与血流量的下降有显著相关性。更多还原

【Abstract】 Objective To explore the correlation between change of blood lipid and MSCT perfusion imaging in steroid-induced femoral head necrosis in adult rabbits.Methods 20 rabbits 1~1.5 years old in age were divided into two group:16 rabbits in experimental group,8 mg/kg Methylprednisolone was injected twice a week;4 rabbits were used as control group.At 2,4,6,8 week after injection,4 rabbits in experimental group and 1 rabbit in contral group were killed respectively.Before killing the rabbits,the blood lipid was examined and MSCT perfusion imaging was done and the correlation between them was analysed.The index of TRIG,CHOL,Perfusion,PEI,TTP,MTT.All femoral heads were undergone pathological investigation.Results Two weeks after injection,blood lipid began increasing,then blood flow of femoral head decreasing obviously with prolongation of injection;PEI and MTT decrease only 4 weeks after injection.There were a negaitive correlation between blood lipid and blood flow of femoral head.Conclusion There were obviously correlation between the level of increasing blood lipid and blood flow decreasing in steroid-induced avascular necrosis of femoral head in rabbit.更多还原