【摘要】 目的:探讨人乳头瘤状病毒DNA检测与细胞学检查在宫颈癌前病变早期诊断中的比较。方法:病例来源于我院门诊及住院病人,均已在普通门诊做巴氏涂片(采用TBS细胞分类法)和高危型HPV-DNA检测,任何一项检查异常均在阴道镜下行多点活检。巴氏涂片以≥ASCUS/AGUS为阳性,HPV-DNA≥1.0pg/ml,宫颈活检病理作为金标准,以≥CIN2为阳性。结果:高危型HPV-DNA检测的敏感性为97.3%;特异性为71.6%;巴氏涂片的敏感性为62.2%;特异性为83.8%;两者相比高危型HPV-DNA检测方法有较高的敏感度和阴性预测值。结论:HPV-DNA检测在宫颈癌前病变早期诊断中的敏感度和阴性预测值都很高,是一种有效的初筛手段。更多还原

【Abstract】 Objective:To evaluate the accuracy of human papillomavirus (HPV) DNA testing for detecting cervical intraepithelial neoplasia (CIN). Methods: Women from our hospital were screened using Papanicolaou (Pap) smears and HPV DNA testing by Hybrid Caputre (HC-II). Women who were positive for high-risk HPV or had Pap results of ASCUS or higher, were considered to have positive screening test results and referred for colposcopy and biopsy. Rusults:The sensitivity of Pap (with a result of ≥ASCUS) for identifying women with CIN2 or higher was only 62.2% compared with 97.3% for HPV testing by HC-II. Differences in specificities were also observed: 83.8% for Pap and 71.6% for HC-II. Conclusion: Testing for HPV has higher sensitivity and predictive value of negative test. It is an effective screening method.更多还原