【摘要】 目的了解促红细胞生成受体(EpoR)在卵巢良性、交界性、恶性上皮性肿瘤组织中的表达,探讨其与上皮性卵巢癌肿瘤发生发展的关系。方法用免疫组化SP法对51例卵巢癌组织、25例交界性上皮性卵巢肿瘤、31例良性上皮性卵巢肿瘤组织中EpoR的表达情况进行了检测。结果EpoR在恶性及交界性上皮性卵巢肿瘤中的强阳性表达率分别为67%、48%,明显高于良性肿瘤组的32%(P<0.05)。在卵巢癌中EpoR的表达与卵巢癌的临床分期有关,Ⅲ~Ⅳ期卵巢癌强阳性表达率73%,明显高于Ⅰ~Ⅱ期的56%(P<0.05),而与细胞分化程度无明显关联。但有淋巴结转移的病例强阳性表达率76%,明显高于无淋巴结的58%。结论EpoR的表达与上皮性卵巢肿瘤的发生发展关系密切。更多还原

【Abstract】 Objective:To investigate the expression of erythropoietin receptor(EpoR)in ovarian epithelial tumor. Methods: The expression of EpoR was detected in malignant, borderline and benign ovarian tissues by immunohistochemical SP method. Results: Intense expression rates of EpoR in malignant, borderline, benign epithelial tumor tissues of ovary were 67%, 48%, 32% respectively. There were a significant difference between malignant, borderline and benign tumors (P<0.05) . In ovarian cancer, the expression of EpoR had a significant relevance to clinical phase but no relevance to pathological grades. The intense expression rate (73%) in phase Ⅲ~Ⅳ of ovarian cancer was much higher than that in phase Ⅰ~Ⅱ(56%) . The intense expression rate (76%) in lymph node metastasis group was much higher than that in no lymph node metastasis group (58%).Conclusion: EpoR is related to the tumorigenesis and progress of the ovarian cancer.更多还原