【摘要】 目的通过测定原发性肝癌患者对5-氟脲嘧啶(5-Fu)、顺铂(DDP)、阿霉素(ADM)、丝裂霉素(MMC)、氨甲喋呤(MTX)、长春新碱(VCR)6种化疗药物的体外敏感性试验,探讨肿瘤药敏试验对原发性肝癌个体化疗的应用价值。方法采用组织块培养-终点染色-计算机图像分析法(TECIA)。结果24例原发性肝癌细胞对6种化疗药物的敏感性由高到低依次为5-Fu、MMC、DDP、ADM、MTX、VCR。结论TECIA法的体外肿瘤药敏试验在原发性肝癌的临床用药及个体化化疗方面具有重要的指导意义。更多还原

【Abstract】 Objective:We collected tissues from cases with primary hepatic carcinoma, then testing their sensitivities to drugs of 5-fluorouracil(5-Fu)、cisplatin (DDP)、adriamycin(ADM)、mitomycin-c(MMC)、methotrexate(MTX) and vincristine (VCR) to evaluate the effects of drugs sensitivity experiment of cancer in clinic individual chemotherapy of primary hepatic carcinoma. Methods: Drug sensitivity was tested by TEIA assay. Results: The sensitivities of 24 cases with primary hepatic carcinoma from high to low were 5-Fu,MMC,DDP,ADM,MTX and VCR. Conclusion: Drug sensitivity test of TECIA assay has guidance value for individual chemotherapy of primary hepatic carcinoma.更多还原