【摘要】 目的:探讨乌体林斯膀胱灌注对大鼠血清白细胞介素-6(IL-6)和膀胱肿瘤生长的影响。方法:制作N-甲基亚硝基脲诱导大鼠原位膀胱癌模型,于第8周行单次或连续(每周1次,共4次)膀胱灌注乌体林斯后,进行病理观察、测量膀胱总重量和检测血清IL-6的水平。结果:单次膀胱灌注乌体林斯的膀胱癌大鼠血清IL-6的水平高于对照组(P<0.05),连续4次膀胱灌注乌体林斯的膀胱癌大鼠血清IL-6的水平高于对照组(P<0.01),膀胱总重量小于对照组(P<0.01),表明膀胱肿瘤的生长被抑制。结论:经尿道膀胱灌注乌体林斯不但可引起局部免疫反应,还能调节外周血的免疫状态,可能起到抑制膀胱肿瘤的生长,达到抗肿瘤作用。更多还原

【Abstract】 Objective: To investigate the effects of intravesical instillation of Utilins injection on orthotopic bladder tumor of rats, the serum levels of interleukin-6 (IL-6) and the weight of bladder tumor . Methods: Orthotopic bladder tumors were established in rats by intravesical administration of N-mmethyl-noitrosourea. Rats with bladder cancer received single or a total of four times (every week) intravesical instillation of Utilins injection from the eighth week. Rats were executed in 24 hours after the last intravesical instillation and their pathologic characters were surveyed. The serum levels of IL-6 and weight of bladder were measured. Results: The levels of serum IL-6 in groups received single and four times intravesical instillation of Utilins injection were significantly greater than those of control (P<0.05, P<0.01). The bladder including tumor in groups with four times Utilins injection instillation weighted less than that in group of control(P<0.01). This revealed that the tumor growth was significantly inhibited. Conclusion: The results suggest that besides local immune activation, Utilins injection instillation also leads to a modulation of peripheral immune mechanisms.更多还原