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S100A4在肺癌中的表达及其与MMP9/TIMP1表达失衡的关系

Expression of fibroblast specific protein-1(S100A4), matrix metalloproteinase 9 (MMP9) and tissue inhibitor of metalloproteinases 1(TIMP1) in human lung cancer and their clinical biological significance

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【作者】 孙忠民陈香丽王鸿雁陈小燕王敏张冠军姚艳

【Author】 Department of Pulmonary Diseases,the First Hospital of Xi’an Jiaotong University(Xi’an 710061) Sun Zhongmin Chen Xiangli Wang Hongyan et al

【机构】 西安交通大学第一医院呼吸内科西安交通大学第一医院呼吸内科 (西安710061)(西安710061)

【摘要】 目的:研究S100A4在人肺癌中的表达及其临床生物学意义,探讨其在肺癌的侵袭和转移中的作用及其与MMP9/TIMP1表达失衡的关系。方法:采用S-P免疫组化法检测50例肺癌及6例正常肺组织中S100A4、MMP9及TIMP1的表达水平。结果:S100A4、MMP9和TIMP1在肺癌中表达显著高于正常肺组织;非小细胞肺癌中表达明显高于小细胞肺癌(P<0.05);腺癌中表达明显高于鳞癌(P<0.05)。S100A4和MMP9表达与非小细胞肺癌临床病理特征关系密切,在有淋巴结转移组与无转移组中两者均有显著性差异(P<0.05)。在肺癌不同临床TNM分期中,S100A4和MMP9阳性表达随临床分期的升高而明显增加,各期间均有显著性差异(P<0.05)。MMP9表达与非小细胞肺癌分化程度密切相关,随分化程度的降低,MMP9阳性率升高(P<0.05);S100A4阳性率随分化程度的降低也有升高趋势,但没显著性差异。S100A4表达与肿瘤大小有密切的正相关关系,随肿瘤体积的增大,S100A4的阳性率升高(P<0.05)。S100A4与MMP9呈正相关(P<0.05);MMP9与TIMP1呈正相关关系(P<0.05)。结论:S100A4和MMP9与肺癌的侵袭和转移有密切的关系,可以作为评估肺癌病人预后的重要指标。TIMP1不是简单对MMP9的局部升高起反应。S100A4参与调节MMP9的表达,则可能为肺癌的治疗开辟一条新的途径。

【Abstract】 Objective:To determine the expression of fibroblast specific protein-1 (S100A4), matrix metalloproteinase 9(MMP9) and Tissue inhibitor of metalloproteinases 1(TIMP1) in human lung cancer, and to investigate the possible roles of S100A4, MMP9 and TIMP1 in the infiltration and metastasis of lung cancer.Methods:Immunohistochemical S-P method was used to detect the expression of S100A4, MMP9 and TIMP1 in 50 lung cancer tissues and 6 normal lung tissues.Results: The expression of S100A4, MMP9 and TIMP1 were up-regulated in lung cancer tissues. Significant differences of the expression rates of S100A4, MMP9 and TIMP1 were found between lung cancer and normal groups (P<0.05), between non-small cell lung cancer and small cell lung cancer(P<0.05) and between adenocarcinoma and squamous cell carcinoma(P<0.05). The expression of S100A4 and MMP9 was closely related to clinicopathological characteristics of non-small cell lung cancer; lymph node metastasis groups had higher S100A4 and MMP9 expressions than without lymph node metastasis groups(P<0.05); In TNM stage, the positive expression of S100A4 and MMP9 increased remarkably fromⅠto Ⅱ, then to Ⅲ+Ⅳ (P<0.05); Expression rate of MMP9 had negative relation with cell differentiation (P<0.05) and S100A4 had positive relation with tumor volume (P<0.05) in non-small cell lung cancer. In lung cancer tissues, there was obvious positive correlation between S100A4 and MMP9, and between MMP9 and TIMP1. Conclusion:S100A4 and MMP9 may play important roles in lung cancer invasion and metastasis; their over expressions could act as a reference to evaluate metastasis and unfavorable prognosis of lung cancer.TIMP1 was not simple response to local increase of MMP9. S100A4 was concerned with modulation of the expression of MMPs, which may inaugurate a new approach to lung cancer therapy.

  • 【文献出处】 陕西医学杂志 ,Shaanxi Medical Journal , 编辑部邮箱 ,2006年05期
  • 【分类号】R734.2
  • 【被引频次】3
  • 【下载频次】121
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