【摘要】 目的:研究瑞芬太尼配伍氯胺酮在小儿门诊手术中应用的安全性和有效性。方法:将60例门诊手术患儿随机分为R组(瑞芬太尼组)和K组(氯胺酮组),每组30例。麻醉诱导采用先静脉注射氯胺酮。麻醉维持:R组为静脉泵注瑞芬太尼;K组为静脉泵注氯胺酮。观察诱导前、诱导后1~3m in及切皮时的血流动力学变化,同时观察麻醉效果(用VA S方法)、麻醉苏醒及不良反应等情况。结果:两组麻醉效果满意,但R组更佳;两组麻醉诱导后血流动力学变化有显著性差异(P<0.05);R组血流动力学变化幅度,呼之睁眼和术后苏醒恢复状况均优于K组(P<0.05)。结论:使用瑞芬太尼的患儿麻醉效果更满意,术后苏醒快,安全性高。更多还原

【Abstract】 Objective:To study the efficacy and safety of remifentanil and ketamine used for the pediatric operation of outpatient.Methods: 60 children undergoing operation were randomly divided into R group(remifentanil group) or K group(ketamine group).Anesthesia was induced with ketamine at first,and was maintained with the continuous infusion of either remifentanil in R group or ketamine in K group.Hemodynamic changes before anesthesia induction,1～3 minute after induction and the time of skin incision,depth of anesthesia,recovery profile of anesthesia,and adverse reactions were observed.Results:Both groups showed satisfactory anesthesia,but R group was better than K group(P<0.05).Hemodynamic changes during anesthesia induction and the time to open eyes on command were significantly fewer and earlier in R group than in K group(P <0.05).Recovery from anesthesia was better in R group than in K group.Conclusion: The anesthetic effect of remifentanil is more potent than that of ketamine,and recovery from anesthesia is faster.更多还原