【摘要】 目的通过分析比较下肢动脉硬化闭塞症(ASO)人群和非动脉硬化闭塞症人群对某些因素暴露情况的不同,来找出与中老年人下肢动脉硬化闭塞症发病存在相关性的危险因素,并找出相对显著的危险因素。方法采用回顾性病例对照研究的方法,对病例组和对照组各80例患者对性别、年龄、肥胖、吸烟、饮酒、糖尿病、高血压、心脑血管疾患、高胆固醇血症、脉压增大等危险因素的暴露情况,建立Logistic回归模型,进行单因素及多因素分析。结果单因素分析结果显示性别、肥胖、血清总胆固醇水平在病例组和对照组之间差异无统计学意义,其余各因素均表现出与下肢ASO发病有不同程度的正相关(P<0.01)。在包括年龄、吸烟、饮酒、糖尿病、高血压、心脑血管疾患的多因素分析中,年龄、吸烟、糖尿病、高血压作为突出相关因素被选入。将脉压增大作为一个危险因素引入后,年龄、吸烟、糖尿病、脉压增大被选入,高血压变得相对不突出。结论在各研究因素中,性别、肥胖、高胆固醇血症与下肢ASO发病的相关性不显著。在其他因素中,高龄、吸烟及糖尿病为突出危险因素。高血压与下肢ASO的发生有较强的相关性,但脉压增大与下肢ASO发病的正相关性与高血压相比更为突出。更多还原

【Abstract】 Objective By analyzing the different degrees of exposure to some risk factors between sufferers of arteriosclerosis obliterans of lower limbs(AOLL) and persons without the disease,to find out the factors correlated with AOLL,and to distinguish the notable risk factors.Methods A retrospective case-control study was applied to analyze the different exposure degrees to some factors of the case and the control.The factors included sex,age,fatness,smoking,drinking,diabetes,hypertension,coronary heart disease(CHD),cerebrovascular occlusion(CVO),hypercholesterolemia,and augment of pulse pressure.The logistic regression was used to analyze the data in every single factor analysis and multi-factor analysis.Results The results of single factor analysis showed that some factors like sex,fatness and hypercholesterolemia,had no significant difference between the two groups.Other factors had an effect on taking place of ASO of lower limbs.During multi-factor analysis about age,smoking,drinking,diabetes,hypertension,CHD CVO,and hypercholesterolemia,the factors chiefly selected were age,smoking,diabetes,and hypertension.When augment of pulse pressure was introduced as a possible risk factor,the age,smoking,diabetes,and augment of pulse pressure were chiefly selected,but hypertension factor became less important.Conclusion Among all the factors,sex,fatness,and hypercholesterolemia have little correlation with the occurrence of ASO of lower limbs.The augment of pulse pressure is more significant than hypertension.更多还原