【摘要】 目的同型半胱氨酸(H cy)作为一种含硫氨基酸是蛋氨酸代谢的中间产物。一些研究报道,同型半胱氨酸在几种肿瘤中表达水平升高。该文旨在研究同型半胱氨酸在更多种类肿瘤中的表达水平。方法收集7种肿瘤(结直肠癌、原发性肝细胞癌、乳腺癌、膀胱癌、肾癌、胃癌和食管癌患)患者和健康人的血浆,共402份,测定其中总同型半胱氨酸及叶酸、维生素B12的浓度,然后,通过统计学方法,比较7种肿瘤患者血浆总同型半胱氨酸及叶酸、维生素B12的测定结果与健康人有无差异。结果血浆总同型半胱氨酸测定结果:结直肠癌、原发性肝细胞癌、乳腺癌、膀胱癌、肾癌、胃癌和食管癌7组血浆总同型半胱氨酸水平与健康对照组比较,均有统计学差异,水平升高(P<0.05),而叶酸与健康对照组比较水平降低(P<0.05),维生素B12与健康对照组比较无统计学上显著差异(P>0.05)。结论同型半胱氨酸在肿瘤中的升高可能具有普遍性。更多还原

【Abstract】 Objective Homocysteine,a highly reactive sulfur-containing amino acid,as an intermediary product of methionine metabolism.Some studys showed that the level of homocysteine is higher in several tumors,so its aim is to evaluate the concentration of homocysteine in more kinds of tumor.Methods Homocysteine,folate and vitaminB₁₂ status of patients suffering with cancer（includeing colorectal cancer,liver cancer,breast cancer,bladder cancer,kidney cancer,gastric cancer and esophageal cancer） was separately compared with that of normal control group,Results Mean homocysteine level in colorectal cancer,liver cancer,breast cancer,bladder cancer,kidney cancer,gastric cancer and esophageal cancer was significantly higher than that in healthy control group（P<0.05）.Mean foalte level in colorectal cancer,liver cancer,breast cancer,bladder cancer,kidney cancer,gastric cancer and esophageal cancer was significantly lower than that in healthy control group（P<0.05）.There were no statistically significant differences between groups in vitamin B₁₂ level.Conclusion The increase of homocysteine in tumors may be universality.更多还原