【摘要】 以HIV病毒中的TATA为识别位点,设计并合成了由四个N-甲基吡咯环和两个脂肪族氨基酸组成的聚酰胺类DNA识别分子———PyPyPyPyβCONH(CH2)6NH2.合成采用片段偶合的手段,利用卤仿反应和DCC/HOBT偶合反应,合成了含4个芳香杂环的聚酰胺,而且将含有两个游离氨基的脂肪族己二胺成功地接到了链尾.并用核磁共振谱和质谱对该化合物进行了表征.更多还原

【Abstract】 A DNA recognizing polyamides molecule,PyPyPyPyβCONH（CH₂）₆NH₂ which contains four-rings of N-methylpyrrole and two amino acids moieties,was synthesized by the chloroform reaction and the DCC/HOBT coupling reaction,and an amino-group of 1,6-Diaminohexane was successfully linked to the polyamide.The structure of the polyamide derivative was confirmed by NMR and MS spectra.更多还原