【摘要】 胆固醇酯转运蛋白(CETP)是杀菌蛋白基因家族的重要成员,其主要功能是介导血浆中的胆固醇酯逆向从外周组织转运至肝脏中。目前,CETP基因被广泛认为是冠状动脉疾病(CHD)易感基因之一,CETP基因位点的遗传差异表明其与高密度脂蛋白浓度的变化有关,而高密度脂蛋白的浓度高低与冠心病的形成有很大的关系。因此,CETP的功能、遗传差异及与冠心病的关系是当前心血管疾病研究中的一个热点。本文较全面地阐述了CETP的生物学特性、功能以及CETP基因多态性与冠心病的关系。更多还原

【Abstract】 Cholesteryl ester transfer protein CETP is a key member of bactericidal gene family and plays an important role in reverse transportation of cholesterol from the peripheral tissues to the liver. CETP is generally regarded as one of coronary heart diseaseCHD susceptibility genes. The polymorphism of CETP reveals that mutations of CETP lead the change of HDL concentration in blood whereas the HDL concentration has been closely associated with occurrence of CHD. Therefore the function and genetic difference as well as the relationship with CHD become a hot research point at present. This paper reviews the recent advance in research of biological characteristics function gene polymorphism of CETP and its relationship with coronary heart disease.更多还原