【摘要】 围脂滴蛋白(perilipin)是脂滴相关蛋白家族的核心成员之一,是定位于脂滴表面的高磷酸化的蛋白,对脂肪组织中甘油三酯的代谢有双重调节作用,既可通过阻止脂肪酶接近脂滴降低基础状态下的脂解,又可促进激素刺激的脂肪分解.Perilipin在脂代谢中发挥重要作用,其表达调控可能与肥胖及其相关代谢疾病如糖尿病、胰岛素抵抗等有重要关系.本文主要介绍了perilipin的发现、命名、结构特征以及激素和转录因子对perilipin的调控,并阐述了其与相关脂肪酶间的相互作用.目前的研究主要集中于围脂滴蛋白(perilipin)和激素敏感脂肪酶(HSL)之间,与新近发现的脂肪酶脂肪三酰甘油脂酶(ATGL)的相互作用则有待于进一步研究.更多还原

【Abstract】 Perilipin is one of the major members in PAT(perilipin, ADRP, TIP-47) protein family, whose members not only have similar sequences but also have similar gene structure. It is a highly phosphorylated adipocyte protein which locates at the surface of the lipid droplet. It serves important functions in double-regulating triacylglycerol metabolism by blocking lipase approaching droplets to reduce rates of basal lipolysis and facilitate hormonally stimulated lipolysis, then regulates the storage and release of TG. Perilipin plays a important role in lipid metabolism. Its expression and regulation may be associated with obesity and related disorders such as diabetes, atheroma and insulin-resistance. This review mainly introduces the discovery, denomination, structual characteristic, function of perilipin, regulation of hormones and transcription factor on perilipin and its interaction with related lipase. Current researches focus on the interaction of perilipin and HSL, but no research on the interaction of perilipin and ATGL.更多还原