【摘要】 目的构建半水硫酸钙和纳米羟基磷灰石为主的复合人工骨材料并对其注射性能、凝固性能和机械强度的影响因素进行考察。方法测试不同液固比条件下复合材料的注射特性,25℃和37℃时分别测试不同液固比、不同二水硫酸钙促凝剂条件下的材料初、终凝时间和压缩强度,均与纯硫酸钙作对比。结果液固比0.50以上时注射性能满意。无论何种液/固比,复合材料的凝固时间均较硫酸钙延长,37℃下的凝固时间较25℃下延长。一定范围内促凝剂用量过大或过小均使凝固时间延长。液固比越大或促凝剂用量越高,材料压缩强度越低。纳米磷灰石含量增大则材料强度降低。结论合理掌握纳米磷灰石的比例,液固比和促凝剂的用量,是开发可注射纳米人工骨的关键。更多还原

【Abstract】 Objective A new composite bone substitute mainly including Calcium sulphate hemihydrate (CSH)and nanometer hydroxyapatite (n-HA) was developed and the factors those influent it’s injection, hardening andmechanical properties were studied. Methods The injectability of composite material under varies liquid-to-so-lid ratio (L/S ratio) were tested. The hardening time and compressive strength of new material under different L/S ratio or Calcium sulphate dehydrate (CSD) amount were tested both at 25℃ and 37℃, all compared with thoseof pure CSH. Results The injectability of new material was desired when L/S ratio more than 0.50. The hard-ening time of composite material were longer than those of CSH under whichever L/S ratio. The hardening timeof all samples at 37℃ were longer than those at 25℃. Whithin certain range, too much of too few CSD amountmade the hardening time longer. The larger L/S ratio or CSD, n-HA content, the less compressive strength.Conclusion Appopriate proportion of n-HA, reasonable L/S ratio and CSD amount were key factors to new in-jectable nano-bone substitute.更多还原