【摘要】 利用含季铵基团瓜尔胶衍生物与三聚磷酸钠在溶液中的离子胶凝反应,在室温、不使用乳化剂或有机溶剂条件下,首次制得一种可生物降解改性瓜尔胶微球,其平均粒径约为140μm且其粒度分布较窄、近似为高斯分布;通过对不同浓度牛血清白蛋白模型药物的负载实验,发现其包封产率可超过80%;通过对载药微球体外释药行为的考察,发现牛血清白蛋白的持续释放时间可达6h以上且其释放百分率受其初始浓度和温度的影响。更多还原

【Abstract】 A biodegradable modified guar gum microsphere was prepared for the first time by ionic gelation of the guar gum derivative containing quarternary ammonium group with tripolyphosphate at room temperature in the absence of emulsifying agent or organic solvent. Its average particle diameter was about 140 μm and the particle size had a narrow and normal gauss distribution. From the loading experiment of bovine serum album (BSA) with various concentrations, it was found that the encapsulation efficiency is more than 80%. By the investigation of in vitro release from the BSA-loaded microsphere, it was found that the BSA had a continuous release for more than 6 hours and the release percentage was affected by the initial concentration of the BSA and temperature.更多还原