【摘要】 研制专门用于离体骨组织疲劳损伤研究的疲劳损伤实验装置,获得骨微损伤用于分析骨的力学性能。根据工业疲劳机及骨疲劳实验的一般原理,自动控制疲劳实验的主要参数包括负载大小、负载频率、负载次数、温度和湿度,达到疲劳损伤实验条件等。研制的SL-2000骨疲劳损伤实验机在0~200 N负载力量、0~10 H z负载频率、0~999999负载次数、~50℃环境温度和~99%环境湿度范围内连续可调。应用该机对大鼠椎体骨疲劳损伤后可以观察到微破裂、染色性弥散性损伤和染色性交叉岔折三种微损伤类型。骨微破裂密度为19.76±15.05#/mm2,微破裂平均长度为36.74±11.51μm,骨染色性弥散性损伤面积比为0.4117%。实验证明该机适合于骨组织疲劳损伤实验,用于建立骨微损伤模型。更多还原

【Abstract】 Having manufactured the bone fatigue damage testing device SL-2000,we applied it to research on bone fatigue damage and on the bone microdamage which can indicate bone biomechanical property.According to the general principle of industry fatigue machine and bone fatigue test,the strength,frequency and times of loading,temperature and degree of wetness were controlled in the SL-2000 Device for making the experiment condition stable.After the fatigue damage to SD rats’ vertebrae,the models of bone microdamage in SD rat were established.0-200 N of strength,0-10 Hz frequency,and 0-999999 times of loading,ambient temperature ～50℃ experiment,and ～99% of the ambient degree of wetness could be adjusted continuously.Three kinds of microdamage such as microcrack,cross-hatch staining,and diffuse staining were observed in the SD rats’ vertebrae fatigue damaged by the device.The microcrack density was 19.76±15.05 #/mm~2,the microcrack length was 36.74±11.51 μm,and the area ratio of diffuse staining was 0.4117%.Therefore the device is suitable for bone fatigue damage test and for establishment of the model of bone microdamage.更多还原