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血液组成交流电特性的研究

Research on Electricity Frequency Property of Blood

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【作者】 胡茂清黄华袁支润陈槐卿邓丽华

【Author】 Hu Maoqing~(1,2) Huang Hua~(3) Yuan Zirun~4 Chen Huaiqing~5 Den Lihua~31(Department of Endocrine,West China Hospital of Sichuan University,Chengdu 610041,China)2(Medical Department,Sichuan Continue Education College of Medical Science,Chengdu 610041,China)3(Biomedical Information Engineering Department,Sichuan University,Chengdu 610065,China)4(Biomechanics Laboratory,Sichuan University,Chengdu 610065,China)5(Institute of Biomedical Engineering,Sichuan University,Chengdu 610041,China)

【机构】 四川大学华西医院内分泌科四川大学医学信息工程系四川大学生物力学实验室四川大学华西医学中心生物医学工程研究室四川大学医学信息工程系 成都610041四川省卫生管理干部学院医学系成都610041成都610065

【摘要】 对人体血液及不同组成、生理和病理(糖尿病)状态的电频谱特性(幅频特性和相频特性),在1 H z~20MH z范围进行了检测分析。血液组成中电阻抗血清最小,其次是血浆、全血、红细胞最大,负相移基本满足血清最大,其次是血浆,全血,最小是红细胞。但问题是血清、血浆中恰无细胞、细胞膜,何来容性效应最大呢;糖尿病属内分泌(血液改变较明显)疾病,糖尿病患者血液电频谱特性有明显且典型性改变:血液电阻抗下降(低频端更显著),负相移增加(高频端更明显)。表明糖尿病人的血液交流导电性增加主要是容性导电的增加,应与红细胞膜变化,红细胞变形能力和聚集性改变相关。相关实验表明,血液电频谱特性的研究,使我们有可能利用电学强有力的理论和手段,从另一个视角去认识血液的一些重要性质,并和其它一些检测分析方法相互补充和印证。

【Abstract】 On the basis of our previous work,the electric frequency property of human blood in different components,in physiological state and in pathological state(diabetes) are tested and analyzed in the range of 1Hz-20MHz progressively.Among the different components of blood;the lowest electrical impedance is serum;the plasma and the whole blood gradually become larger,the blood corpuscle is the largest one.Otherwise,the negative phase of serum is the largest,the plasma and the whole blood are lower,and the blood corpuscle is the lowest.Here,the question is why the effect of the electric capacity of serum and plasma is the biggest in the condition of no cell and cell membrane;diabetes mellitus is an endocrine disorder in which blood changes obviously,the electric frequency property of the blood of diabetic patients changes markedly;the electrical impedance of blood decreases(more obviously with low frequency),the negative phase increases(more obviously with high frequency).These indicate that the increase of electric conductivity in diabetic patients’ blood is due to electric capacitance conductivity that is related to the changes of cell membrane,deformation abilities and aggregation of RBC.Related experiments demonstrate again that with the progressing of research in the electric frequency property of blood,we may use the theory and method of electricity to examine some important characters of blood in a different way,and so to corroborate other tests and analyses.

【基金】 中国博士后科学基金资助项目(中博基(2001)5号)
  • 【文献出处】 生物医学工程学杂志 ,Journal of Biomedical Engineering , 编辑部邮箱 ,2006年01期
  • 【分类号】R318.04
  • 【被引频次】8
  • 【下载频次】147
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