【摘要】 目的:研究超声引导下经阴道卵巢打孔术(TOD)治疗克罗米酚(CC)耐药性多囊卵巢综合征(PCOS)不孕患者的排卵和妊娠情况。方法:2003年12月至2005年06月就诊的CC耐药PCOS患者,阴道超声介导下经阴道卵巢打孔。术后常规用CC+补佳乐促排卵方案,观察排卵率和妊娠情况,并随访1年内妊娠情况。结果:38例患者采用经阴道卵巢打孔术治疗后血清睾酮较初诊时明显下降(p<0．04)。术后第1周期21人有排卵,排卵率55．26％。另18人仍然无效。第1周期有3例妊娠,1例流产。第1周期后再用促排卵药B超监测有排卵或自然周期BBT双相但未怀孕7例。随访6月内共5例妊娠。结论:对于CC耐药的PCOS患者,采用超声引导下经阴道卵巢打孔技术是继腹腔镜下卵巢打孔术之后一种简便、有效的选择。更多还原

【Abstract】 Objective: To study the follicle development and pregnancy in CC-resistance Polycystic Ovarian Syndrome (PCOS) patients with anovulatory infertility after the therapy of ultrasound-guided transvaginal ovarian drilling (TOD). Methods: From Dec 2003 to June 2005, 38 cases with CC-resistance PCOS women were treated with TOD. Following TOD, ovulation and pregnancy results were monitored after the ovaries were stimulated by routine protocol with CC. Results: After the therapy of TOD, serum testosterone level in those women was marked lower than before (p<0.04). In the next cycle, 21 patients (55.26%) experienced follicle development and ovulation. 3 patients were pregnant, one was abortive. After that, 7 patients had ovulation after COH cycle or BBT double-lines with natural cycle. Within 6 month after the procedure, a total of 5 patients were pregnant. Conclusion: TOD can be a novel method to treat CC-resistance PCOS patients as convenient and effective as laparoscopy ovarian drilling (LOD).更多还原