【摘要】 通过比较基因组学的方法研究发现,牛分支杆菌与肺结核杆菌基因组的同源性为99.95%,但在牛分枝杆菌基因组中有11个缺失区,大小从1kb到12.7kb,遗传信息的缺失引起牛分枝杆菌的基因组减小;牛分枝杆菌与肺结核分枝杆菌H37Rv间存在着2437个单核苷酸多态性(SNPs),与肺结核分枝杆菌CDC1551间存在着2423个单核苷酸多态性(SNPs),牛分支杆菌与肺结核分枝杆菌在编码细胞壁和分泌蛋白上变异程度也是巨大的。研究结果揭示了牛分支杆菌与肺结核分枝杆菌的遗传关系,为研究分支杆菌疫苗和诊断试剂提供理论依据,对牛肺结核病的防治有着非常重要的意义。更多还原

【Abstract】 Through the comparision of genome between the Mycobacterium bovis and Mycobacterium tuberculosis,it is concluded that the homology of Mycobacterium bovis and Mycobacterium tuberculosis are 99.95% respectively,but there are 11 deletants(range,from 1kb to 12.7kb in the genome of the Mycobacterium bovis.The absence of genetic information resulted in reduction of genome in Mycobacterium bovis.There are 2437 single-nucleotide polymorphisms(SNPs) between the Mycobacterium bovis and Mycobacterium tuberculosis H37Rv,2423 SNPs,between the Mycobacterium bovis and Mycobacterium tuberculosisCDC1551.The extent of variation is obvious on Codocyte cellwall and secreted protein between the two.The finding reveals the genetic relationship between Mycobacterium bovis and Mycobacterium tuberculosis,which offers a theoretical basis for Mycobacterium vaccine and diagnostic reagent,and is of great significance for the prevention and treatment of Bovine pulmonary tuberculosis.更多还原