【摘要】 本文分析了盐度1‰和15‰下诺氟沙星肌肉注射给药(剂量10mg/kg)和盐度15‰下药饵口服给药(剂量15mg/kg和30mg/kg)后南美白对虾血淋巴中药代动力学。在盐度1‰和15‰下,南美白对虾肌注给药后血药浓度的变化趋势基本相似,血药浓度与时间关系曲线适合用二室模型来描述,其药动学方程分别为C0=35.422×e-9.778t+4.363×e-0.165t和C0=35.144×e-13.335t+7.888×e-0.608t,但两盐度下部分药动学参数差别较大。药饵口服给药时,给药剂量与血药浓度未呈明显的正相关,且血药浓度—时间关系曲线均表现出双峰现象。以30mg/kg剂量药饵口服给药后,药峰出现的时间分别为给药后4h和12h,峰浓度分别为2.86μg/mL和2.04μg/mL;以15mg/kg剂量给药时也得到相似的双峰现象,但第二峰浓度出现的时间为8h。更多还原

【Abstract】 The pharmacokinetics of norfloxacin were analyzed in whiteleg shrimp（Penaeus vannamei） following intramuscle injection and oral administration.The curvilinear trend of the hemolymph concentration versus time data were almost similar following intramuscle injection at salinities of 1 and 15.The hemolymph concentration versus time at the salinities of 1 ppt and 15 ppt were well described by a two-department model,and the pharmacokinetic models were C₀=35.422×e^-9.778t+4.363×e^-0.165t at salinity of 1 and C₀=35.144×e^{-13.335 t}+7.888×e^-0.608t at salinity of 15.There were significant differences in some pharmacokinetic parameters of norfloxacin in P. vannamei between at salinities of 1 and 15.The distribution half-life(t_1/2α),disposition half-life(t_1/2β),area under curve（AUC）,total body clearance（CLs） and apparent volume of distribution（Vd）following intramuscle injection at salinity of 1 were 0.071h,4.208h,30.06μg·h/mL,332.7 mL/kg·h and 2016 mL/kg,respectively.The corresponding values at salinity of 15 were 0.052h,1.140h,15.61μg·h/mL,640.6 mL/kg·h and 1054mL/kg,respectively.Following oral administration at dose of 30（mg/kg）,the hemolymph concentration-time profile of norfloxacin in whiteleg shrimp exhibited two peaks of hemolymph norfloxacin concentration,which occurred at 4h and 12h,and the hemolymph norfloxacin peak concentrations were 2.86μg/mL and 2.04μg/mL,respectively.The area under curve and total body clearance following oral administration were 43.50μg·h/mL and 689.7 mL/kg·h.The hemolymph concentration-time profile of norfloxacin following oral administration at dose of 15mg/kg also exhibited two peaks,which was similar to that at dose of 30mg/kg.But the second Cmax at dose of 15mg/kg occurred at 8h.There were no marked proportion between the dosage of norfloxacin and the hemolymph norfloxacin concentration.更多还原