【摘要】 报道了由N,N-二羟乙基苯胺一步法合成对-(二(2-氯乙基))胺基苯甲醛.DMF与POCl3于0℃下搅拌反应45min,再于0℃下一次性加入N,N-二羟乙基苯胺的DMF溶液并搅拌,慢慢升温至110℃,继续反应2h得到标题化合物.反应物料比分别是:n(N,N-二羟乙基苯胺)∶n(POCl3)=1∶3.3,mt(总的DMF)∶m(N,N-二羟乙基苯胺)=4∶1,m1(POCl3加入前烧瓶中的DMF)∶m2(溶解N,N-二羟乙基苯胺的DMF)=3∶1.对-(二(2-氯乙基))胺基苯甲醛的产率为95.6%.更多还原

【Abstract】 That N,N-Bis-hydroxyethylaniline was conveted to p-(Bis（2-chloroethyl）aminobenzaldehyde by one-stage process is reported in this paper.DMF and POCl₃ were stirred to react successively at 0℃ for 45 min,subsequently,a solution of N,N-Bis-hydroxyethylaniline and DMF was rapidly added to the stirred reactive mixture at 0℃,and the whole reactive mixture was heated gradually to 110℃ to continue for 2h,and thus the topic compound was obtained.Reactive materials rates were as follows:n（N,N-Bis-hydroxyethylaniline） : n（POCl₃）=1:3.3,mt（total DMF）: m（N,N-Bis-hydroxyethylaniline）=4:1,m₁（DMF in flask before addition of POCl₃）:m₂（DMF dissolving N,N-Bis-hydroxyethylaniline）=3 :1.The yield of p-(Bis（2-chloroethyl）aminobenzaldehyde was 95.6%.更多还原