【摘要】 目的:观察大豆异黄酮对高脂血症大鼠血脂的影响。方法:选择成年雌性SD大鼠50只,体重280～320g,随机分为四组:空白对照组:喂饲基础饲料;高脂模型组:喂饲高脂饲料;其余2组分别喂饲添加300、600mg/kg大豆异黄酮的高脂饲料。实验第6周末,空腹12h,5%戊巴比妥钠麻醉后,心脏取血及制备10%肝组织匀浆,测定血清总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、脂蛋白脂酶(LPL)、肝脂酶(HL)等指标。结果:与高脂组比较,SI剂量组大鼠肝脏中的TC、TG、LDL-C显著降低(p<0.01),HDL-C显著增高(p<0.05),LPL活性显著增强(p<0.05)。结论:大豆异黄酮具有明显的降血脂作用。更多还原

【Abstract】 Objective: To study the influence of soy isoflavones on serum lipid level in Hyperlipidemia rats. Methods: 50 SD female rats were randomly divided in 4 groups: normal diet control, high fat diet, low dose SI (300mg/kg bw)+high fat diet, and high dose SI (600mg/kg bw) + high fat diet; rats of normal diet control were fed with normal diet, and rats of the remainder groups were fed with high fat diet. After 6 weeks, rats were killed and have detected serum lipid level and activity of LPL and HL in blood. Results: Compared with the group of SI diet, the TC, TG, LDL-C levels of the group of high fat diet were significantly higher, the HDL-C level were significantly lower, the activity of LPL in serum increased obviously. Conclusion: These results suggested that soy Isoflavones can decrease the serum lipid level obviously.更多还原